Not only do you need to have a perfect query letter, synopsis and sample pages (backed up by a perfect manuscript), you also need to query the right agent at the right time.
Which is why I'd like to offer my congratulations to my sister Paula* (find her here at ViewReview) on finding an agent and hope it leads to the publication of her first novel very soon.
*Last seen running out the door shouting ‘I’m just doing coffee with my agent.’
Writer Nathan Bransford had these Wise words to say about finding an agent:
There are many ways of going about this, and, believe it or not, none of them involve telling an agent they're a cutiepatootie.